19th and 20th century medicine:

John Hughlings Jackson

(1835 - 1911)

A Study of Convulsions

The fit usually begins, it is to be observed, in that part of the face, of the arm, and oft the leg, which has the most varied uses. ... the fits which begin in the hand begin usually in the index finger and thumb; fits which begin in the foot begin usually in the great toe.

... it may be that the order of frequency mentioned point merely to an order of frequency in liability of parts to become diseased. ... Parts which have the most varied uses will be represented in the central nervous system by most ganglion cells.

All of Jackson's statements are correct!

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